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2 edition of Heterogeneity of antigen expression of colorectal tumours and their metastases found in the catalog.

Heterogeneity of antigen expression of colorectal tumours and their metastases

M. C. Crowson

Heterogeneity of antigen expression of colorectal tumours and their metastases

by M. C. Crowson

  • 214 Want to read
  • 18 Currently reading

Published by University of Birmingham in Birmingham .
Written in English


Edition Notes

Thesis (M.D.) - University of Birmingham, Dept of Surgery, 1988.

StatementM. C. Crowson.
ID Numbers
Open LibraryOL13902396M

  The number of metastatic lesions is closely correlated with prognosis in most cancers. The aim of this study was to clarify the relationship between individual heterogeneity of metastatic tumor sizes and prognosis in patients with multiple pulmonary metastasis of colorectal Cited by: 1. In colon cancer, HOXA5 is downregulated, and its re-expression induces loss of the cancer stem cell phenotype, preventing tumor progression and metastasis. Tumor regression by HOXA5 induction .

Tumor-associated macrophages (TAMs) provide a nurturing microenvironment for metastasis and are concomitantly key determinants of the efficacy of anticancer strategies. TAM represent an extremely heterogeneous population in terms of cell morphology, functions, and tissue localization. Colorectal liver metastases (CLM) display a high heterogeneity Cited by: 3.   Cancer/testis antigens (CTA) are suitable targets for immunotherapy of human malignancies, and clinical trials are mainly focusing on MAGE-A3. However, the heterogeneous intratumor expression of CTA may hamper the effectiveness of CTA-directed vaccination through the emergence of CTA-negative neoplastic clones. We investigated the intratumor heterogeneity Cited by:

  Purpose: To evaluate whether patients with metastatic gastrointestinal adenocarcinomas refractory to chemotherapy harbor tumor-reactive cytotoxic T cells. Experimental Design: Expansion of CD8+ tumor-infiltrating lymphocytes (TIL) and cancer cell lines was attempted from gastrointestinal cancer metastases Cited by:   The dissemination of tumour cells is the prerequisite of metastases and is correlated with a loss of epithelial differentiation and the acquisition of a migratory phenotype, a hallmark of Cited by:


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Heterogeneity of antigen expression of colorectal tumours and their metastases by M. C. Crowson Download PDF EPUB FB2

Table IV Concordance of antigen expression in primary colorectal carcinomas and regional lymphnode metastases percentage of concordance number of differing observations expression in expression in primary more metastases more than metastases Cited by: 5.

A significantly diminished percentage of cells stained from the metastases in lymph nodes and distant sites. Pearson correlation coefficients showed that the antigenic expression of the metastasis in the lymph node was a better indicator of the antigenic expression of the metastasis Cited by: The expression of carcinoembryonic antigen (CEA) in gastric malignancies has been assessed using a monoclonal antibody in an immunoperoxidase technique.

Of primary tumours examined, 92% reacted with the antibody. Metastases Cited by:   Phenotypic heterogeneity has been observed in most malignancies, which represents a considerable challenge for tumor therapy.

In recent decades, the biological function and clinical significance of the human leukocyte antigen Cited by: 9. We here explore the soluble Human Leukocyte Antigen-G (sHLA-G) expression level as clinical biomarker in metastatic colorectal cancer (mCRC).

To this aim the sHLA-G protein was. Treatment of metastatic colorectal cancer (mCRC) is generally based on genetic testing performed in primary tumor biopsies, but whether the genomic status of primary tumors is identical to that of metastases is not well known.

We compared the gene expression profiles of formalin-fixed paraffin-embedded (FFPE) biopsies of colorectal primary tumors and matched liver by: 3. The heterogeneity of metastatic tumor sizes may be an indicator for prognosis in patients with multiple pulmonary metastases of colorectal cancer who underwent by: 1.

Tumor heterogeneity represents indeed one of the main causes of therapeutic failure, and its decoding remains a major ongoing challenge in the field.

Liquid biopsy is the sampling and analysis of non-solid. Tumor-specific preferential conservation of antigen processing and presentation genes suggests immune surveillance exerts strong selective pressures on most human colorectal tumors during growth. Tumor-specific conservation is likely due to selection, but other factors such as greater replication fidelity could also explain Cited by: 5.

Types of Tumor Heterogeneity. There are several types of genetic heterogeneity in cancer biology. The most well known is interpatient tumor heterogeneity (Fig. 1A), whereby no two patients with the same subtype of tumor behave the same clinically, with or without may be related to host factors, such as tumor Cited by:   We analyzed the immunohistochemical expression of three epitopes of the tumor-associated glycoprotein 72 (TAG) in whole cross-sections of primary colorectal carcinomas and in regional lymph node metastases Cited by: 9.

Whole tumor and non-tumor samples from an expanded CRC patient cohort were then further analyzed for expression changes of genes involved in sphingolipid, fatty acid or prostaglandin metabolism, using custom PCR arrays, in order to compare their expression status between normal colon and tumor.

The Membrane Antigens of Human Colorectal Cancer Cells: Demonstration with Monoclonal Antibodies of Heterogeneity within and between Tumours and of Anomalous Expression of HLA-DR* A.

Cited by: mary lesion, serum carcinoembryonic antigen level, number of pulmonary metastases, and D max-min were in-dependent prognostic factors.

Conclusions. The heterogeneity of metastatic tumor sizes may be an indicator for prognosis in patients with multiple pulmonary metastases of colorectal. Tumour heterogeneity describes the observation that different tumour cells can show distinct morphological and phenotypic profiles, including cellular morphology, gene expression, metabolism, motility, proliferation, and metastatic potential.

This phenomenon occurs both between tumours and within tumours. A minimal level of intra-tumour heterogeneity. Nonclassical MHC class I HLA-G antigen expression is tissue specific and is thought to play a role in tolerance of the semiallogeneic fetus by the maternal immune system.

Ectopic expression of HLA-G by tumor cells provides them with an additional mechanism of escape from immunosurveillance by host cytotoxic effector mechanisms. The aim of this study was to assess the expression Cited by: Metastasis being the main cause of breast cancer (BC) mortality represents the complex and multistage process.

The entrance of tumor cells into the blood vessels and the appearance of circulating tumor cells (CTCs) seeding and colonizing distant tissues and organs are one of the key stages in the metastatic cascade. Like the primary tumor Author: Maxim E.

Menyailo, Maria S. Tretyakova, Evgeny V. Denisov. In addition, the expression of the mammary tumor metastasis-associated cell-surface glycoprotein gp on untransfected and transfected MTC.4 cells indicated that the cell populations of higher. Metastasis of colorectal cancer (CRC) is directly linked to patient survival.

We previously identified the novel gene Metastasis Associated in Colon Cancer 1 (MACC1) in CRC and demonstrated its importance as metastasis inducer and prognostic biomarker. Here, we investigate the geographic expression pattern of MACC1 in colorectal adenocarcinoma and tumor Cited by:   The fact that various immune cells, including macrophages, can be found in tumor tissue has long been known.

With the recent introduction of the novel concept of macrophage differentiation into a classically activated phenotype (M1) and an alternatively activated phenotype (M2), the role of tumor Cited by:. The exclusion of immune cells from the tumor microenvironment has been associated with poor prognosis in the majority of cancers.

We report that when considering 21 solid cancer types, immune cell exclusion is widely associated with the presence of a stem cell-like phenotype in tumors (“stemness”). Stemness positively correlates with higher intratumoral heterogeneity Cited by: 7.Colorectal cancer is not one disease but rather a collection of neoplastic diseases.

Due to heterogeneity in the disease biology, therapy response, and prognosis, extensive disease .Colorectal carcinomas are composed of heterogeneous cell subpopulations which may be instrumental in conferring metastatic potential and therapeutic refractoriness to these tumours.

To assess cellular heterogeneity, the expression has been examined of two oncodevelopmental antigens, carcinoembryonic antigen Cited by: